LEVEL 01 · Basic biology
Peptides as biological messengers
How short amino-acid chains participate in signalling, regulation and structural biology, and why sequence order matters.
Narrative review of established biology
Research library
RESEARCH TOPICS AND HOW TO READ THEM.
Each entry describes a research theme, the type of investigation it rests on and the level of evidence available. We list no citations we have not verified; specific studies are added only after editorial review.
LEVEL 01 · Basic biology
From sequence to folded structure
The relationship between amino-acid order, conformation and biological behaviour, including the role of the chemical environment.
Foundational science overview
LEVEL 01 · Basic biology
Affinity, selectivity and receptor occupancy
What binding data can and cannot tell us about a compound's likely biological effect in a living system.
Methodological overview
LEVEL 02 · Preclinical research
Tissue specificity in bioregulator research
How claims of tissue-directed activity are constructed, and which experimental designs would be required to support them.
Critical appraisal
LEVEL 01 · Basic biology
Stability, degradation and half-life
Enzymatic degradation, chemical stability and structural modification as determinants of measurable exposure.
Concept overview
LEVEL 02 · Preclinical research
Reading preclinical peptide research
A framework for separating cell and animal findings from conclusions about people, with common inference errors.
Research literacy
LEVEL 04 · Clinical evidence
Trial design, endpoints and uncertainty
Phases, controls, endpoint selection and the limits of inference in human peptide research.
Research literacy
LEVEL 01 · Basic biology
Identity, purity and analytical confidence
The roles of chromatography and mass spectrometry in characterising a peptide and verifying what a sample contains.
Analytical overview
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